Vital
Our verdict
A well-dosed combination of two researched muscle ingredients, HMB and dileucine, that suits active adults over 60 doing strength training. Check the high vitamin D dose with your doctor first.
from $66.65$79.95per bottle in the 6-pack
Check today's price on the official site →Official store · 90-day money-back guarantee
What is Advanced Muscle Plus?
Advanced Muscle Plus is the newer, more targeted muscle product from Advanced Bionutritionals. Instead of a general amino acid blend, it uses two branded ingredients chosen for their effect on muscle building and muscle breakdown, and it is meant to be taken after workouts.
| Form | 180 tablets, 6 tablets a day (30-day supply) |
|---|---|
| Main ingredients | 2,000 mg DL185 dileucine, 1,500 mg myHMB, 200 mcg vitamin D3 |
| Formulated by | Dr. Greg Eckel, ND |
| Store rating | 4.5 out of 5 from 26 customer reviews on the official site |
| Guarantee | 90 days (refund minus shipping) |
Ingredients and doses
| Ingredient | Per daily serving | What the research says |
|---|---|---|
| DL185 dileucine | 2,000 mg | Dileucine is two leucine molecules joined together. A small 2021 study in young men found it raised muscle protein synthesis more than the same amount of free leucine; a 10-week training study reported larger strength gains than placebo. Research in older adults is still limited. |
| myHMB (calcium HMB) | 1,500 mg | HMB is a breakdown product of leucine. Meta-analyses in older adults suggest it helps preserve muscle mass, especially during bed rest or inactivity. The usual research dose is about 3 g a day, so this is half that. |
| Vitamin D3 | 200 mcg (8,000 IU) | Supports normal muscle function. This is twice the 4,000 IU upper limit set for daily long-term use without medical supervision, so ask your doctor, especially if you take other vitamin D. |
Unlike many muscle products, the doses are fully disclosed on the label.
Does it work? What the research says
Both active ingredients have a scientific rationale. HMB has the longer track record in older adults, particularly for slowing muscle loss during illness or inactivity. Dileucine is promising but newer, with most studies done in younger people. Combined with regular strength training and enough protein, this formula could give a modest extra push.
The sales page makes strong claims, such as building muscle "even with little exercise" and results "up to 3 times faster". We would not count on that. Supplements like this amplify the effect of training; they do not replace it. Our muscle guide has a simple home routine to start with.
Who it suits, and who should skip it
Good fit
- Adults over 60 who already do strength exercise and want to support their progress
- People recovering their strength after a period of inactivity, with their doctor's approval
- Those who prefer clearly dosed, branded ingredients
Skip it or ask your doctor first
- Anyone who already takes vitamin D, has high calcium levels, kidney stones or kidney disease, unless their doctor approves
- People who do not plan to exercise
- Those on a tight budget: it is one of the pricier products in the range
Pros and cons
Pros
- Fully disclosed doses
- Two researched ingredients for muscle building and breakdown
- Designed to pair with Advanced Amino Formula
Cons
- Very high vitamin D dose (8,000 IU) that not everyone needs
- Six tablets a day
- Few customer reviews so far
- Higher price than most muscle supplements
Price, guarantee and where to buy
| Package | Per bottle | Total | Shipping |
|---|---|---|---|
| 1 bottle (1 month) | $79.95 | $79.95 | plus shipping |
| 3 bottles (3 months) | $71.65 | $214.95 | Free |
| 6 bottles (6 months) | $66.65 | $399.90 | Free |
Prices listed on the official store on October 26, 2026. They change from time to time, so check the current offer before ordering. Every package is a one-time payment on the order page we checked.
That works out to about $2.22 a day on the 6-bottle pack. Advanced Bionutritionals offers a 90-day money-back guarantee on every package: you can return the bottles, even empty, within 90 days of purchase for a refund. You pay the return shipping. Buying from the official store is the only way to be sure you get genuine, in-date stock and the guarantee.
How to take it: Take the daily serving after your workout; on rest days, take it with your first meal. Do not combine with other vitamin D supplements unless your doctor agrees.
Check today's price on the official site →Official store · 90-day money-back guarantee
Keep reading
Amino Formula vs Muscle Plus
Keeping muscle after 60Frequently asked questions
Does Advanced Muscle Plus work without exercise?
HMB may help limit muscle loss during inactivity, but for building muscle and strength you still need resistance exercise. Expect the best results when you combine it with training at least twice a week.
Is the vitamin D in Advanced Muscle Plus too high?
It contains 200 mcg (8,000 IU) per daily serving, above the 4,000 IU upper limit for unsupervised long-term use. Some doctors prescribe this much to correct a deficiency, but you should check with yours, and get your level tested.
Can I take it with Advanced Amino Formula?
Yes, the company designed them to be used together: the amino formula daily and Muscle Plus around workouts.
How long until I notice results?
The company suggests 4 to 8 weeks for changes in strength and muscle tone. Track simple measures, such as how many chair stands you can do in 30 seconds.
