Vital
Our verdict
One of the most complete 'cellular energy' formulas we have seen, with fully listed doses. Best for adults over 60 with low energy whose doctor has ruled out other causes. Expect gradual change, not a jolt.
from $66.65$79.95per bottle in the 6-pack
Check today's price on the official site →Official store · 90-day money-back guarantee
What is Advanced Mitochondrial Formula?
Advanced Mitochondrial Formula targets the "power plants" inside your cells. As we explain in why you may feel tired after 60, mitochondria tend to become less efficient with age, and levels of compounds they rely on, such as NAD+ and CoQ10, fall. This formula combines eleven nutrients involved in that energy machinery.
| Form | 60 capsules, 2 a day (30-day supply) |
|---|---|
| Key ingredients | Niacinamide 200 mg, D-ribose 250 mg, acetyl-L-carnitine 190 mg, curcumin 180 mg, CoQ10 50 mg, PQQ 5 mg, resveratrol 25 mg and more |
| Formulated by | Dr. Frank Shallenberger, MD |
| Store rating | 4.4 out of 5 from 111 customer reviews on the official site |
| Guarantee | 90 days |
Ingredients and doses
| Ingredient | Per daily serving | What the research says |
|---|---|---|
| Niacinamide (vitamin B3) | 200 mg | A precursor of NAD+, which mitochondria need to make energy. Raises NAD+ levels; long-term benefits for energy are still being studied. |
| D-ribose | 250 mg | A sugar used to build ATP, the cell's energy currency. Studied mainly for fatigue in specific conditions at much higher doses (5 g). |
| Acetyl-L-carnitine | 190 mg | Carries fats into mitochondria to be burned for energy. Some trials in older adults found less physical and mental fatigue at higher doses. |
| Curcumin (95%) with BioPerine | 180 mg + 10 mg | Turmeric's active compound, paired with black pepper extract to improve absorption. Antioxidant and anti-inflammatory research. |
| Coenzyme Q10 | 50 mg | Essential for energy production; levels fall with age and with statin drugs. Meta-analyses show a modest reduction in fatigue scores. |
| R-alpha lipoic acid | 50 mg | Antioxidant involved in energy metabolism. |
| Quercetin | 65 mg | Plant flavonoid with antioxidant properties. |
| Trans-resveratrol | 25 mg | Polyphenol studied for its effect on sirtuins, enzymes linked to cellular aging. |
| PQQ | 5 mg | Linked in lab studies to the creation of new mitochondria. Small human studies at 10 to 20 mg. |
| Magnesium (malate) | 45 mg | Needed for hundreds of energy-related reactions; malate is a gentle form. |
Every dose is disclosed. Several ingredients are below the amounts used in the studies, which is common in multi-ingredient formulas; the idea is that they work together.
Does it work? What the research says
Each ingredient has a reasonable scientific basis, and CoQ10 and carnitine have the most human evidence for reducing fatigue. The combination has not been tested as a whole in published trials, and some doses are modest, so think of it as broad support rather than a guaranteed fix.
The sales page says niacinamide raises NAD+ levels "by 3,000%". Niacinamide does raise NAD+ quickly, but a blood marker is not the same as how energetic you feel. Give it six to eight weeks and judge by how your days feel.
Who it suits, and who should skip it
Good fit
- Adults over 60 who feel their energy has dropped and have had a check-up
- People taking statins who want CoQ10 plus other energy nutrients in one product
- Those who would otherwise buy CoQ10, PQQ, carnitine and curcumin separately
Skip it or ask your doctor first
- Anyone on blood thinners (warfarin and others) without their doctor's approval: CoQ10, curcumin and resveratrol may interact
- People with gallbladder problems (curcumin)
- Anyone with unexplained new fatigue who has not seen a doctor yet
Pros and cons
Pros
- Eleven ingredients with every dose disclosed
- Only two capsules a day
- Combines CoQ10, PQQ, carnitine and NAD+ support in one
Cons
- The most expensive product in the range
- Some doses are lower than in clinical studies
- Fewer customer reviews than the bestsellers
Price, guarantee and where to buy
| Package | Per bottle | Total | Shipping |
|---|---|---|---|
| 1 bottle (1 month) | $79.95 | $79.95 | plus shipping |
| 3 bottles (3 months) | $71.65 | $214.95 | Free |
| 6 bottles (6 months) | $66.65 | $399.90 | Free |
Prices listed on the official store on October 26, 2026. They change from time to time, so check the current offer before ordering. Every package is a one-time payment on the order page we checked.
That works out to about $2.22 a day on the 6-bottle pack. Advanced Bionutritionals offers a 90-day money-back guarantee on every package: you can return the bottles, even empty, within 90 days of purchase for a refund. You pay the return shipping. Buying from the official store is the only way to be sure you get genuine, in-date stock and the guarantee.
How to take it: Take two capsules a day, ideally with a meal that contains some fat to help absorb CoQ10 and curcumin.
Check today's price on the official site →Official store · 90-day money-back guarantee
Keep reading
Why am I so tired after 60?Frequently asked questions
What does Advanced Mitochondrial Formula do?
It supplies nutrients involved in cellular energy production, such as CoQ10, niacinamide (for NAD+), carnitine, D-ribose and PQQ, to support normal energy levels as mitochondria age.
Can I take it with statins?
Statins lower CoQ10 levels, so many people on statins take CoQ10. Still, check with your doctor before adding any supplement to your medicines.
Is it safe with blood thinners?
Ask your doctor first. CoQ10 may reduce the effect of warfarin, and curcumin and resveratrol can affect bleeding.
How long does it take to feel a difference?
Most mitochondrial nutrients need four to eight weeks of daily use. Changes tend to be gradual.